منابع مشابه
Oncometabolites: linking altered metabolism with cancer.
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we revi...
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Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis. Recently, metabolites that can promote tumorigeneis by altering the epigenome have been identified. These 'oncometabolites' include the tricarboxylic acid...
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The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states-cancer being one. Otto Warburg demonstrated that cancer cells, in the presence of oxygen, undergo glycolysis by reprogramming their metabolism-termed "aer...
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16 wHat’s On tHe weB Cytogenetically normal acute myeloid leukemia (CyN-AmL) makes up 40 to 50 percent of cases of adult AmL. The heterogeneous nature of CyN-AmL makes prognosis uncertain, and despite the clinical heterogeneity, induction therapy remains largely uniform. Technological advances in DNA sequencing, however, are providing new insights into the molecular basis of CyN-AmL, suggesting...
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During tumorigenesis, the shift from oxidative phosphorylation to glycolysis in ATP production accounts for the dramatic change in the cellular metabolism and represents one of the major steps leading to tumour formation. The so-called Warburg effect is currently considered something more than a mere modification in the cellular metabolism. The paradox that during cancer cell proliferation the ...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2019
ISSN: 1759-5061,1759-507X
DOI: 10.1038/s41581-019-0210-z